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The concentrations of serum lipids and other indices were not different between the groups at either intervention period. These results suggest that supplementation with 1.5 mg/d MK-4 accelerated the degree of OC gamma-carboxylation. The serum ucOC and GlaOC concentrations in the MK-4 group were significantly different from those in the placebo group at 2 wk. Serum undercarboxylated OC (ucOC) concentration decreased, and the gamma-carboxylated OC (GlaOC) and GlaOC/GlaOC+ucOC ratio that indicates the degree of OC gamma-carboxylation increased significantly at 2 and 4 wk compared with that at baseline in the MK-4 group. The most marked effects of MK-4 intake were observed on serum osteocalcin (OC) concentrations. The participants aged 53-65 y were randomly assigned to 2 groups and supplemented with 1.5 mg/d of MK-4 or a placebo for 4 wk (n=20 for each group). The study was performed as a randomized double blind placebo-controlled trial. The aim of this study is to examine the effects of the supplementation of 1.5 mg/d MK-4 for 4 wk on bone and lipid metabolism in healthy postmenopausal Japanese women. However, it is not known whether supplementation with low dose MK-4 has beneficial effects on bone metabolism in healthy women. It has been reported that treatment with a pharmacological dose (45 mg/d) of menaquinone-4 (MK-4) prevents bone loss in postmenopausal women. This product is suitable for vegetarians and vegans. There is no known upper limit for vitamin K, and the recommended dose for dietary deficient people is 1 capsule daily. Vitamin K can be obtained from the diet and the amount you need depends on your age and sex. Vitamin K2 contributes to the normal maintenance of bones.Īlso consider the Vitamin D3/K2 combination as both K2 and D3 contribute to the normal maintenance of bones. MK4 is supposed to direct calcium directly to bone (since calcium can float around and settle in the arteries and other places that would cause harm). The Japanese used 15 mg/day in their experiment to beat osteoporosis but I only take 5mg/day. MK7 can last in the body for 36 hours, much longer than MK4 so Metabolics uses MK7. I've been taking 5mg capsules of Vitamin K2, MK4 (Menatetranone) for two years. There are 2 forms of Vitamin K, MK4 and MK7. Researchers have shown that tissue levels of K2 are lower when DHP is high. These contain a mutated form of vitamin K1, which is created when vitamin K1 rich plant oils are synthetically hydrogenated.
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Another reason for K2 deficiency is the introduction of Trans fats in margarine and butter substitutes.
Vitamin k2 mk4 free#
Most chickens do not roam free to eat grass and only grass fed animals have sufficient chlorophyll levels to convert to Vitamin K2. Most dairy and meat cattle are grain fed, either partially or totally. The main reason for Vitamin K2 deficiency is that our food just does not contain enough. K2 is found in the yolk of eggs, the fat of meat, in butter and in a fermented soya product known as Natto. Very little K1 is converted to K2 and it is essential that K2 is taken in the diet or through supplementation. K2 activates 2 important proteins, one of which takes the calcium into the bones and the teeth and one which escorts calcium out of the soft tissues such as the arteries. These are found in green leafy vegetables. K1 activates special proteins that help the blood to clot. There are 2 important forms of Vitamin K, Vitamin K1 and Vitamin K2. It is only in the last 5 years that the importance of Vitamin K has become apparent. Many of you may not be aware of the great importance of Vitamin K2. Metabolics Vitamin K2 has been updated to reflect this now contains 150mcg of Vitamin K2 per capsule rather than the previous 75mcg.
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Recent research suggests that supplemental K2 doses should be higher than previously thought. Note: This product has been recently updated.